表观遗传学是指基于非基因序列改变所致基因表达水平变化。表观遗传的现象目前已知的包括DNA甲基化、基因组印记、母体效应、基因沉默、核仁显性、休眠转座子激活和RNA编辑等。
其中组蛋白（Histone）的修饰作用是表观遗传学研究的一个重要领域。Histone H3与H2A、H2B和H4一起参与真核细胞中染色质的结构。组蛋白H3通过承受几种不同类型的表观遗传修饰，参与并影响许多细胞进程，如转录激活/失活、染色体包装、DNA损伤/修复。这些修饰，包括甲基化、瓜氨化、乙酰基化、磷酸化、小泛素相关修饰化、泛素化及二磷酸腺苷核糖基化。主要发生在组蛋白H3的N末端尾区域上，这导致核小体结构重构成更容易接近的开放构象的转录复合物。在大多数物种中，组蛋白H3主要在赖氨酸9,14,18,23和56处乙酰化; 在赖氨酸4,9,27,36和79处甲基化; 并分别在ser10，ser28，Thr3和Thr11磷酸化。组蛋白修饰的深入研究能更好地了解细胞过程的表观遗传调控。
西美杰为您整理并推荐Agrisera公司经过验证的，高质量的组蛋白表观遗传修饰抗体，产品如下：
|
产品名称 |
货号 |
适用物种 |
产品详情 |
|
H3K18me1 | Histone H3 (monomethylated Lys18) |
AS16 3181 |
人 |
|
|
H3K27ac | Histone H3 acetylated lysine 27 (ChIP grade) |
AS16 3195 |
拟南芥、人、小鼠、大鼠 |
|
|
H3K27me3 | Histone H3, trimethylated lysine 27 (H3K27me3) |
AS16 3193 |
拟南芥、人、杨树、玉米等 |
|
|
H3K37me1 | Histone H3 (Monomethylated Lys37) |
AS16 3186 |
人 |
|
|
H3K4me3 | Histone H3, trimethylated lysine 4 |
AS16 3190 |
拟南芥、人等 |
|
|
H3K56me1 | Histone H3 (monomethylated Lys56) |
AS16 3187 |
人 |
|
|
H3K9ac | Histone H3, acetylated lysine 9 |
AS16 3198 |
拟南芥、人等 |
|
|
H3K9me2 | Histone H3 dimethylated lysine 9 |
AS16 3194 |
人、番茄 |
|
|
H3R2me1 | Histone H3 (monomethylated Arg2) |
AS16 3167 |
秀丽隐杆线虫、人 |
|
|
H3S10p | Histone H3 (p Ser10) (affinity purified) |
AS16 3635 |
人 |
注：产品名称命名方式以组蛋白名称开始，如H3；单一字母的氨基酸简称，如K代表赖氨酸，以及在蛋白质的位置；修饰的种类，Me即甲基化、P即磷酸化、Ac即乙酰化、Ub即泛素化。
为满足广大表观遗传学研究方向客户的需求，西美杰联合专业抗体品牌Agrisera推出表观遗传学相关抗体促销活动！
活动内容如下：
活动时间：即日起至6月30日
活动对象：仅限终端客户参加
促销规则：促销产品限时“7折”特惠
促销产品：除上述小编列举的组蛋白表观遗传修饰抗体外，更有50多种表观遗传学相关抗体正在进行促销，请见以下促销产品清单：
|
产品名称 |
产品货号 |
|
5-fC | 5-formylcytosine |
AS16 3165 |
|
5-hmC | 5-hydroxymethylcytosine (monoclonal) |
AS16 3164 |
|
5-hmC | 5-hydroxymethylcytosine (polyclonal) |
AS16 3166 |
|
5-mC | 5-methylcystosine (monclonal antibody for MeDIP/IF) |
AS16 3162 |
|
5-mC | 5-methylcystosine (monclonal) |
AS16 3161 |
|
5-mC | 5-methylcystosine (monclonal, clone 33D3) |
AS16 3163 |
|
Acetylated lysine (25 µl, clone 7F8) |
AS10 707-25 |
|
Acetylated Lysine (polyclonal) |
AS15 3018 |
|
Acetylated Lysine, ALP conjugated |
AS15 3019 |
|
Acetylated Lysine, FITC conjugated |
AS15 3020 |
|
H2A.XS139p | H2A.X phosphorylated serine 139 |
AS16 3199 |
|
H3 | Histone 3 core | (monoclonal) |
AS16 3197 |
|
H3K18me1 | Histone H3 (monomethylated Lys18) |
AS16 3181 |
|
H3K18me2 | Histone H3 (dimethylated Lys18) |
AS16 3182 |
|
H3K18me3 | Histone H3 (trimethylated Lys18) |
AS16 3183 |
|
H3K27ac | Histone H3 acetylated lysine 27 (ChIP grade) |
AS16 3195 |
|
H3K27me3 | Histone H3, trimethylated lysine 27 (H3K27me3) |
AS16 3193 |
|
H3K27me3S28p | Histone H3 (trimethylated Lys27, p Ser28) |
AS16 3184 |
|
H3K36me3 | Histone H3 trimethylated lysine 36 (ChIP grade) |
AS16 3196 |
|
H3K37me1 | Histone H3 (Monomethylated Lys37) |
AS16 3186 |
|
H3K4me1T6p | Histone H3 (monomethylated Lys4, p Thr6) |
AS16 3171 |
|
H3K4me3 | Histone H3, trimethylated lysine 4 (H3K4me3) |
AS16 3190 |
|
H3K4me3 | Histone H3, trimethylated lysine 4 (H3K4me3) (10 µg) |
AS16 3190-10 |
|
H3K4me3T6p | H3 (trimethylated Lys4, p Thr6) |
AS16 3172 |
|
H3K56me1 | Histone H3 (monomethylated Lys56) |
AS16 3187 |
|
H3K56me3 | Histone H3 (trimethylated Lys56) |
AS16 3188 |
|
H3K9ac | Histone H3, acetylated lysine 9 |
AS16 3198 |
|
H3K9me2 | Histone H3 dimethylated lysine 9 |
AS16 3194 |
|
H3R17me2(asym) | Histone H3 (asym-dimethyl Arg17) |
AS16 3180 |
|
H3R2me1 | Histone H3 (monomethylated Arg2) |
AS16 3167 |
|
H3R2me2(sym)K4me2 | Histone H3 (sym-dimethylated Arg2, dimethyl Lys4) |
AS16 3185 |
|
H3R8me2(asym) | Histone H3 (asym-dimethylated Arg8) |
AS16 3177 |
|
H3R8me2(sym) | H3 Histone 3 (sym-dimethylated Arg8) |
AS16 3178 |
|
H3S10p | Histone H3 (p Ser10) (affinity purified) |
AS16 3635 |
|
H3S10p | Histone H3 (p Ser10) (affinity purified, 10 µl) |
AS16 3635-10 |
|
H3S10p | Histone H3 (p Ser10) (serum) |
AS16 3636 |
|
H3S10pT11p | Histone H3 (p Ser10, p Thr11) |
AS16 3179 |
|
H3T3pK4ac | Histone H3 (ac Lys4, p Thr3) |
AS16 3170 |
|
H3T3pK4me1 | Histone H3 (p Thr3, monomethylated Lys4) |
AS16 3168 |
|
H3T3pK4me2 | Histone H3 (dimethylated Lys4, p Thr3) |
AS16 3169 |
|
H3T6p | Histone H3 (p Thr6) |
AS16 3173 |
|
H3T6pK9me1 | Histone H3 methylated at Lys9 (K9) |
AS16 3174 |
|
H3T6pK9me2 | Histone H3 (dimethylated Lys9, p Thr6) |
AS16 3175 |
|
H3T6pK9me3 | Histone H3 (trimethylated Lys9, p Thr6) |
AS16 3176 |
|
H4K16ac | Histone H4 (ac Lys16) |
AS16 3189 |
|
m6A | N6-methyladenosine (monoclonal) |
AS17 4120 |
|
m6A | N6-methyladenosine (polyclonal) |
AS17 4121 |
|
Methylated Lysine |
AS15 3021 |
|
Methylated Lysine, APC conjugated |
AS15 3022 |
|
Methylated Lysine, FITC conjugated |
AS15 3023 |
西美杰做为Agrisera中国区代理为广大客户提供经过验证的高质量抗体，优质的售前咨询服务以及良好的抗体售后支持。此外西美杰代理的Lifespan、Mybiosource一抗、检测试剂盒以及SeraCare（KPL）二抗、底物全方位助力于科学研究实验。
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